Hi DM,
If you havent been in the gym in a while I would start with your second option to get back into it. This would give you a full body work out 3x's per week and also give you plenty of time for rest and recuperation. I would use more compound excercises than isolation ones when starting off (e.g. A compound movement would be assorted barbell & dumbell benchpress movements over the isolation movements like flys and cable crossovers) The compund excersises will incorporate more overall muscle to move the weight.
You could then run on your off days. I would stick with that routine for 4-6 weeks and then change to your first suggestion.
Good luck !!
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