My experience varies quite widely. Sometimes I feel it right away, sometimes it takes a while for me to notice or for it to get particularly bothersome or unbearable. Psychology also comes in, as I generally seem to feel pain more against someone I consider to be a difficult or dangerous opponent, and I shrug it off against someone I figure I can beat while half asleep. Even on the latter end of the spectrum I won't be ignoring it completely and will adjust so that it's no longer a threat to me, and adjustment always creates openings, so after grabbing the testicles you might find that it's no longer the only option available to you, and maybe you can create some space and work your way out. Consistently liver shots hurt me much worse than the balls. I find it also depends on what's being done, if it's a reversal where I'm getting the balls squished between my thigh and their arm I'm going to go with it since there likely isn't a great pay-off in grimacing through the pain. I could end up getting reversed anyway.
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