Orthodox is the more common stance simply because there is more right handers than left handers.
Most of the time it depends on which hand you are. What you want, is to have your strong hand as your rear hand, for your power shots.
That's usually the case. Some people prefer to have their stronger, more dominant hand up front, which is something I am experimenting with now.
Go with what is comfortable for you. If it is awkward you sure as hell don't want to be using it to box.
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