All pressure points really are are bundles nerves in specific locations. Do I buy that you can strike a series of them and knock a guy out? Not until I see it. But I have used them in grappling situations.
I've a fairly skinny guy (6'0", 155) so when I grapple with bigger guys I get tossed around alot. When a guy has a you locked up and you can't get out. A finger press to the throat, a thumb in the crook of the elbow or the armpit, the side of the hand directly beneath the nose, or even a quick love-handle twist will get an opponent to loosen up long enough for me to move.
Would I use one when standing? Only the occassional knuckle-punch to the arm pit or forearm to the base of the neck.
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